Research Results and Updates
Vascular Study Results
LIMb Study
New study shows rapid assessment and treatment of end-stage peripheral artery disease (PAD) may reduce the risk of leg amputation by over 50%.
People with advanced PAD can develop pain at rest, ulcer and gangrene in their feet. This is called chronic limb-threatening ischaemia (CLTI). Surgery to restore blood supply to the leg is required to prevent amputation.
In Leicester, we have aimed to see and treat people with CLTI within two weeks of referral since 2018. To achieve this we set up a rapid-acces Vascular Limb Salvage (VaLS) clinic.
The Leg Ischaemia Management collaboration (LIMb) study compared a group of patients treated in Leicester in 2019-2022 to a historical group from 2013-2015.
"Even after accounting for differences in the two groups of people this represents a 57% reduction in major amputation risk."
To read more about the LIMb Study and results, please visit https://theconversation.com/peripheral-artery-disease-the-bi...
We thank all the patients that participated in the LIMb study. We
also thank George Davies and the George Davies Charitable Trust (UK Registered
Charity no. 1024818) for the generous charitable donation that funded both the
LIMb study and the VaLS clinic.
Vascular Study Updates
6th January 2026
UK-MAT Trial - Participant Recruitment Underway
The UK Metformin Aneurysm Trial is now underway. Non-diabetic patients diagnosed with small Abdominal Aortic Aneurysm (AAA) across the nation are being offered the opportunity to participate in this potentially ground-breaking research.
Click here to access the recent BBC News article for information about the trial and to read about Philip, who is one of the first patients to sign up and take part.
If you would like to find out more about participating in UK-MAT, and to contact the trial team directly, please visit the Active Studies page.
6th January 2026
MOSAIC 2 Study: Programme Grant Update
The MOSAIC 2 Study team are excited to announce that the programme grant funding officially started in November 2025, and the team is now working towards Phase 1 of the grant, which focuses on the MOSAIC 2 adaptation study.
The adaptation study aims to work with 20 patients or carers and 20 practitioners or service planners to adapt the programme so that it can be delivered in community services and primary care practices. This study consists of three stages, involving online group workshop meetings to adapt the MOSAIC intervention and co-design materials. We’re looking forward to holding our first workshop in February next year.
More information about how to take part in the adaptation study can be found on the Active Studies page, along with a link to contact the team directly and register your interest.